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MOTS-C for exercise performance — 10mg vs 40mg vial?

I've been reading about MOTSC as an "exercise mimetic" — apparently it activates AMPK similar to exercise and can improve mitochondrial function and metabolic health. I'm not super active desk job, some surfing on weeke…

Raj K.·

I've been reading about MOTS-C as an "exercise mimetic" — apparently it activates AMPK similar to exercise and can improve mitochondrial function and metabolic health.

I'm not super active (desk job, some surfing on weekends) and I'm interested in it more for the metabolic benefits than athletic performance. A few questions:

  1. 10mg vs 40mg vial — is the 40mg just better value or is there a reason to start smaller?
  2. What's the typical dosing protocol? I've seen 5mg/week and 10mg/week mentioned
  3. Can you stack it with NAD+? Seems like they'd be complementary for mitochondrial function
  4. Any side effects to watch for?

4 Replies

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Nina S.·Apr 1

MOTS-C is one of my favourite peptides to recommend. Start with the 10mg vial at 5mg/week (split into 2-3 doses) to assess tolerance. Once you're comfortable, the 40mg vial is much better value.

Yes, it stacks beautifully with NAD+ — they target different aspects of mitochondrial function. MOTS-C activates AMPK while NAD+ supports the NAD+/NADH ratio. Together they're a comprehensive mitochondrial support protocol.

Side effects are minimal. Some people report mild fatigue in the first week as the metabolic pathways upregulate.

Dan P.·Apr 2

I've been running MOTS-C + NAD+ for about 2 months. The combination is excellent — noticeably more energy and my fasted blood glucose improved from 5.4 to 4.8 mmol/L. Definitely get the 40mg vial if you plan to run it for more than 2 weeks.

Chris W.·Apr 2

Been using 5mg/week for a month. As a freediver the mitochondrial efficiency benefits are noticeable — my breath holds have improved and I recover faster between dives. No side effects for me.

Mito Labs Team·Apr 30

Hey Raj,

It's great to see your interest in MOTS-C! You're spot-on about it being an "exercise mimetic" — it can definitely help with mitochondrial function and metabolic health, even if you're not super active.

For your questions:

  1. 10mg vs 40mg: The 40mg vial is primarily a better value option if you plan to use it over a longer period. Starting with the 10mg vial is a good idea to see how your body responds, as Nina suggested. Once you're comfortable, you can switch to the 40mg for cost efficiency.

  2. Dosing: A common protocol is 5mg per week, split into 2-3 doses. Once you assess your tolerance, you might consider increasing to 10mg/week depending on your goals and how your body responds.

  3. Stacking with NAD+: Absolutely, they can be complementary. MOTS-C activates AMPK pathways, while NAD+ supports overall mitochondrial health. Together, they create a robust support system for your metabolism.

  4. Side effects: Typically minimal, but as mentioned, some people experience mild fatigue initially. It's your body's way of adjusting to new metabolic activity.

Given your weekend surfing and desk job, starting with a lower dose could be a smart way to ease into it. Let us know how it goes, and feel free to keep the questions coming!