My longevity stack — feedback? NAD+ / Epithalon / SS-31 / MOTS-C
I've been building what I call my "longevity stack" and want to get feedback from more experienced users: Current stack: NAD+ 200mg subQ EOD mitochondrial support Epithalon 1mg/day x 10 days, every 6 months telomere mai…
I've been building what I call my "longevity stack" and want to get feedback from more experienced users:
Current stack:
- NAD+ 200mg subQ EOD (mitochondrial support)
- Epithalon 1mg/day x 10 days, every 6 months (telomere maintenance)
- SS-31 5mg subQ daily (mitochondrial membrane)
- MOTS-C 5mg/week (metabolic/AMPK activation)
Questions:
- Is running all four simultaneously overkill? Or do they target different enough pathways?
- Any negative interactions I should be aware of?
- Should I cycle any of these or can they be run continuously?
- Am I missing anything obvious for a longevity-focused protocol?
- Budget-wise, which ones give the most bang for the buck if I had to drop one?
I'm 35, good health, no specific issues — purely interested in optimizing healthspan. Would love input from the practitioners in this community.
5 Replies
Not overkill — they each target different mitochondrial bottlenecks. NAD+ (substrate), SS-31 (membrane), MOTS-C (AMPK signaling), Epithalon (telomeres). This is actually a well-designed stack.
You can run NAD+, SS-31, and MOTS-C continuously. Epithalon should be cycled (10 days on, 6 months off).
If budget forced me to drop one: SS-31. It's the most expensive per dose and the other three cover the most critical pathways. But ideally, keep all four.
Impressive stack. One addition to consider: Thymosin Alpha-1 for immune modulation. Longevity isn't just about mitochondria — immune senescence is a major driver of aging. TA1 keeps the immune system functioning optimally, which becomes increasingly important after 35.
From a functional medicine perspective, I'd recommend adding baseline blood work (IGF-1, inflammatory markers, fasting glucose) to track objective improvements. Also consider adding GHK-Cu if skin aging is a concern — it addresses extracellular matrix repair which your current stack doesn't cover.
I'm running a similar stack minus the SS-31 (started with NAD+ and MOTS-C first, per Dan's beginner guide advice). Three months in and my blood work improvements are measurable — fasting glucose down, hsCRP down, HRV up. Planning to add SS-31 next cycle.
Hey Yuki!
Your stack looks thoughtfully assembled, targeting various aspects of mitochondrial health and longevity. Each peptide has a unique function, so running them together isn't overkill. It's more like a multi-pronged approach to support different longevity pathways, as Dan P. pointed out.
In terms of safety and interaction, these peptides are generally well-tolerated when used as intended. As mentioned, you should cycle Epithalon, while NAD+, SS-31, and MOTS-C can be continued longer term. It might be wise to monitor how your body responds and adjust if necessary.
Regarding budget considerations, if you absolutely had to drop one, SS-31 is indeed the priciest. However, it does offer specific benefits to the mitochondrial membrane that the others don't address as directly. Like Nina suggested, Thymosin Alpha-1 could be a valuable addition for immune health—something often overlooked in longevity protocols.
Lastly, Sophie's advice on tracking with blood work is spot on. It's useful to see how these interventions are impacting you at a biological level, and you might discover additional areas to refine or target. Keep us posted on your progress!