MOTS-C 10mg
Mitochondrial exercise mimetic — activates AMPK, improves insulin sensitivity, enhances fat metabolism. Standard dose vial.
Low Stock — Selling Quickly
SKU: ML-MOTSC-20MG
💰 Volume Discounts:
Buy 3+ vials = 10% off · Buy 5+ vials = 15% off
MOTS-C is a mitochondrial-derived peptide encoded within the mitochondrial genome (12S rRNA). Discovered in 2015 by researchers at the University of Southern California, it is one of the first mitochondrial peptides identified to have systemic hormonal effects. MOTS-C activates AMPK (AMP-activated protein kinase) — the master metabolic switch — producing effects that closely mimic those of aerobic exercise. It is nicknamed the "exercise mimetic peptide." It also translocates to the cell nucleus in response to metabolic stress, directly regulating gene expression.
Related Products
AOD9604 5mg
Growth hormone fragment for targeted fat reduction — stimulates lipolysis and inhibits lipogenesis without affecting blood sugar or growth.
GHK-Cu 100mg
Naturally occurring copper peptide complex studied in research on tissue remodelling and gene expression.
FeaturedRetatrutide (RT3-GLP) 10mg
Triple receptor agonist studied in clinical research on GLP-1, GIP, and glucagon pathway modulation.
Retatrutide (RT3-GLP) 20mg
Triple receptor agonist (GLP-1/GIP/glucagon) — 20mg vial offers a lower cost per mg than the 10mg vial.
Community
See all →My longevity stack — feedback? NAD+ / Epithalon / SS-31 / MOTS-C
I've been building what I call my "longevity stack" and want to get feedback from more experienced users: **Current stack:** - NAD+ 200mg subQ EOD (mitochondrial support) - Epithalon 1mg/day x 10 days, every 6 months (telomere maintenance) - SS-31 5mg subQ daily (mitochondrial membrane) - MOTS-C 5mg/week (metabolic/AMPK activation) **Questions:** 1. Is running all four simultaneously overkill? Or do they target different enough pathways? 2. Any negative interactions I should be aware of? 3. Should I cycle any of these or can they be run continuously? 4. Am I missing anything obvious for a longevity-focused protocol? 5. Budget-wise, which ones give the most bang for the buck if I had to drop one? I'm 35, good health, no specific issues — purely interested in optimizing healthspan. Would love input from the practitioners in this community.
SS-31 (Elamipretide) — the mitochondrial peptide nobody talks about
I've been deep-diving into mitochondrial peptides and SS-31 is genuinely fascinating. It targets cardiolipin in the inner mitochondrial membrane and helps restore electron transport chain efficiency. In plain English: it helps your mitochondria produce energy more efficiently, especially in cells that are aging or under stress. The research shows benefits for: - Heart function (originally developed for heart failure) - Exercise capacity in older adults - Kidney function - Possibly neurodegeneration I've been running 5mg subQ daily for 3 weeks. Subjectively I notice: - More sustained energy without the ups and downs - Better exercise recovery (I do hot yoga daily) - Less brain fog in the afternoons It stacks well with NAD+ and MOTS-C for a comprehensive mitochondrial protocol. Curious if anyone else is using it?
MOTS-C for exercise performance — 10mg vs 40mg vial?
I've been reading about MOTS-C as an "exercise mimetic" — apparently it activates AMPK similar to exercise and can improve mitochondrial function and metabolic health. I'm not super active (desk job, some surfing on weekends) and I'm interested in it more for the metabolic benefits than athletic performance. A few questions: 1. 10mg vs 40mg vial — is the 40mg just better value or is there a reason to start smaller? 2. What's the typical dosing protocol? I've seen 5mg/week and 10mg/week mentioned 3. Can you stack it with NAD+? Seems like they'd be complementary for mitochondrial function 4. Any side effects to watch for?